EFFECTIVENESS OF ALDOSE REDUCTASE INHIBITORS FOR DIABETIC GASTROENTEROPATHY WITH CONSTIPATION

We present a diabetic patient with long-standing constipation complica ted by paralytic ileus and septic shock, She successfully recovered fr om a critical condition, and her diabetes was well controlled, However , the constipation did not improve even after the administration of co nventional medications, Epalrestat, an aldose reductase inhibitor (ARI ), improved her bowel motility and autonomic cardiovascular dysfunctio n, as evident from her heart rate and blood pressure response, Gastroe nteropathy is a major diabetic complication which may cause disturbed bowel motility leading to serious enterobacterial infections, thus, it s amelioration is important, ARI may be beneficial in the treatment of diabetic gastroenteropathy refractory to conventional therapies.