RELAPSE IN THE EXTERNAL AUDITORY-CANAL OF ACUTE PROMYELOCYTIC LEUKEMIA AFTER TREATMENT WITH ALL-TRANS-RETINOIC ACID

Authors
TOBITA T SHINJYO K YANAGI M TAKESHITA A OHNISHI K OHNO R
Citation
T. Tobita et al., RELAPSE IN THE EXTERNAL AUDITORY-CANAL OF ACUTE PROMYELOCYTIC LEUKEMIA AFTER TREATMENT WITH ALL-TRANS-RETINOIC ACID, Internal medicine, 36(7), 1997, pp. 484-486
Citations number
19
Categorie Soggetti
Medicine, General & Internal
Journal title
Internal medicine → ACNP
ISSN journal
09182918
Volume
36
Issue
7
Year of publication
1997
Pages
484 - 486
Database
ISI
SICI code
0918-2918(1997)36:7<484:RITEAO>2.0.ZU;2-B
Abstract
A 54-year-old female was admitted to our hospital for gingival bleedin g and was diagnosed as acute promyelocytic leukemia (APL), She receive d induction therapy according to the AML92 protocol of the Japan Adult Leukemia Study Group (JALSG) with all-trans retinoic acid (ATRA) plus chemotherapeutic agents, She achieved complete remission, but one yea r later had a relapse in her external auditory canal without leukemic cell in the bone marrow, Extramedullary disease is rare in APL, This c ase suggests the importance of careful observation for extramedullary relapse in patients who are treated with ATRA.