Bio-encapsulation within sol-gel glasses

The sol-gel process opens new possibilities in the field of biotechnology. Enzymes such as glucose oxydase and lipase can be trapped within sol-gel gl asses without loosing their bioactivity. Small analytes diffuse through the pores of the silica matrix allowing in-situ biocatalytic reactions to be p erformed. Escherichia coli bacteria have also been encapsulated. Their cell ular organization is preserved and they still exhibit noticeable enzymatic activity, even on dried xerogels. Antibody-antigen recognition has been sho wn to be feasible within 'sol-gel matrices and whole cell protozoa have bee n used as antigens for blood tests with human sera.