Linkage studies of SOX13, the ICA12 autoantigen gene, in families with type 1 diabetes

SOX13 is a member of the SOX family of transcription factors that encodes t he type 1 diabetes autoantigen, ICA12. The SOX13 gene maps at chromosome 1q 31.3-32.1 near a region containing a susceptibility locus for type 1 diabet es. SOX13 was assessed as a candidate susceptibility gene. Analysis of the SOX13 gene identified a number of single nucleotide polymorphisms and a pol ymorphic CA dinucleotide repeat. Linkage and association studies indicate t hat SOX13 is unlikely to make a substantial contribution to type 1 diabetes susceptibility. (C) 2001 Academic Press.