Analysis of SLC19A2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in Pima Indians

Authors
Thameem, F Wolford, JK Bogardus, C Prochazka, M
Citation
F. Thameem et al., Analysis of SLC19A2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in Pima Indians, MOL GEN MET, 72(4), 2001, pp. 360-363
Citations number
17
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR GENETICS AND METABOLISM
ISSN journal
10967192 → ACNP
Volume
72
Issue
4
Year of publication
2001
Pages
360 - 363
Database
ISI
SICI code
1096-7192(200104)72:4<360:AOSO1E>2.0.ZU;2-T
Abstract
Mutations in the SLC19A2 gene cause thiamine-responsive megaloblastic anemi a (TRMA) frequently combined with diabetes mellitus and deafness. Type 2 di abetes mellitus is heritable and a region on 1q21-q23 encompassing SLC19A2 was linked with the disease in Pima Indians and Caucasians. We therefore in vestigated this candidate gene in selected diabetic and nondiabetic Pimas a nd found no variants. We conclude that mutations in SLC19A2 do not contribu te to type 2 diabetes in this population. (C) 2001 Academic Press.