In patients with severe brain injury, brain edema, elevated intracranial pr
essure, and cerebral ischemia are accountable for a significant morbidity a
nd mortality. New invasive methods of monitoring attempt to foresee the phy
siopathological mechanisms responsible for the production of secondary brai
n injuries. The available methods for monitoring severely brain-injured pat
ients, their potential usefulness, advantages, and disadvantages are review
ed.