Post-traumatic cerebral ischemia is associated with a poor prognosis. Optim
ization of cerebral perfusion and blood flow thus plays a key role in conte
mporary head injury management However, understanding of the pathophysiolog
y of severe head injury is required for optimal patient management. This ar
ticle explains the relationships between cerebral blood flow and metabolism
and summarizes the current understanding of how these parameters can be he
lpful in the treatment of patients with severe head injuries.