GRAFT-VERSUS-HOST DISEASE-LIKE ERUPTION IN A PATIENT WITH NON-HODGKINS-LYMPHOMA

Graft-versus-host disease (GVHD) is most commonly seen as a complicati on of bone marrow transplantation, although it can occur whenever tiss ue or blood products are given whereby immunologically competent donor lymphocytes react against host tissues, A 65-year-old man with non-Ho dgkin's lymphoma developed a severe widespread erosive eruption of the skin and mucosal surfaces, Clinically and histologically it was ident ical to cutaneous GVHD even though the patient had never received tiss ue or blood products. He failed to respond to conventional therapy for GVHD, but his skin improved significantly on treating his underlying lymphoma, which eventually proved fatal. There are two previous report s of GVHD associated with malignancy but we believe this to be the fir st case secondary to a lymphoma.