Determination of the stereochemistry of hydride transfer from NADPH to FADcatalyzed by VlmR, a flavin reductase from the valanimycin biosynthetic pathway

Authors
Skae, P Parry, RJ
Citation
P. Skae et Rj. Parry, Determination of the stereochemistry of hydride transfer from NADPH to FADcatalyzed by VlmR, a flavin reductase from the valanimycin biosynthetic pathway, ORG LETT, 3(8), 2001, pp. 1117-1119
Citations number
21
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
8
Year of publication
2001
Pages
1117 - 1119
Database
ISI
SICI code
1523-7060(20010419)3:8<1117:DOTSOH>2.0.ZU;2-0
Abstract
The stereospecificity of hydride transfer from NADPH to FAD catalyzed by VI mR, a flavin reductase from the valanimycin biosynthetic pathway has been d etermined. By using stereospecifically deuterated NADPH, it has been shown that the 4-pro R hydrogen of NADPH is transferred.