A novel traceless resin-bound guanidinylating reagent for secondary aminesto prepare N,N-disubstituted guanidines

We report the development of a solid support linked guanidinylating reagent . This reagent consists of a urethane-protected triflyl guanidine attached to the resin via a carbamate linker. It allows for rapid synthesis of guani dines from a variety of amines, It provides access to N-alkyl/aryl- or N,N- dialkylguanidines under mild conditions. Cleavage with 50% TFA produces tar get molecules in high yields and purity. The ability to guanidinylate secon dary amines is a significant feature of this guanidinylating reagent.