Convergent synthesis of peptide conjugates using dehydroalanines for chemoselective ligations

Protein and peptide conjugates such as glycopeptides, prenylated peptides, and lipopeptides play essential roles in biology, A rapid and convergent en try into a variety of these compounds is described, The methodology involve s the introduction of a dehydroalanine into peptides and subsequent chemose lective conjugate addition of an appropriate thiolate nucleophile, includin g farnesylthiolate or thioglycosides.