Enantioselective synthesis of beta-hydroxy acid derivatives via a one-pot aldol reaction-dynamic kinetic resolution

Authors
Huerta, FF Backvall, JE
Citation
Ff. Huerta et Je. Backvall, Enantioselective synthesis of beta-hydroxy acid derivatives via a one-pot aldol reaction-dynamic kinetic resolution, ORG LETT, 3(8), 2001, pp. 1209-1212
Citations number
43
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
8
Year of publication
2001
Pages
1209 - 1212
Database
ISI
SICI code
1523-7060(20010419)3:8<1209:ESOBAD>2.0.ZU;2-W
Abstract
Combining dynamic kinetic resolution with an aldol reaction provides access to P-hydroxy ester derivatives with high enantiomeric purity (up to 99% ee ) in a one-pot procedure, Only simple starting materials are required in th is enantioselective process, and preformation of a silyl enol ether is not necessary.