Some of the most interesting cases in pediatric practice evolve through tim
e. What may begin as a clear, well defined problem with a predictable natur
al history and an accepted intervention strategy may develop into a more co
mplex, multi-faceted set of problems. It is these children who potentially
provide clinicians with new insights into behaviors. This case of a colicky
infant illustrates the wide spectrum of behavioral and physiological sympt
oms that emerge from a specific underlying behavioral phenomenon. It also e
mphasizes the significant benefit derived from a longitudinal perspective o
f developmental events.