Repeated inhibitory effects of NPY on hippocampal CA3 seizures and wet dogshakes

Citation
K. Klemp et Dpd. Woldbye, Repeated inhibitory effects of NPY on hippocampal CA3 seizures and wet dogshakes, PEPTIDES, 22(3), 2001, pp. 523-527
Citations number
24
Categorie Soggetti
Biochemistry & Biophysics
Journal title
PEPTIDES
ISSN journal
01969781 → ACNP
Volume
22
Issue
3
Year of publication
2001
Pages
523 - 527
Database
ISI
SICI code
0196-9781(200103)22:3<523:RIEONO>2.0.ZU;2-8
Abstract
Intracerebroventricular injection of NPY inhibits epileptiform seizures and seizure-related "wet dog shakes" (WDS) following electrical stimulation of the dentate gyrus or subiculum. This study examined the effects of NPY on seizures and WDS elicited in hippocampal CA3. Like in the other hippocampal regions, NPY significantly inhibited both seizures and accompanying WDS co nsistent with in vitro data. The identification of an additional antiepilep tic hippocampal target for NPY could prove therapeutically relevant conside ring that the hippocampal formation is a frequent seizure focus in human ep ilepsy. The effects of NPY were found to persist on seven repeated NPY inje ction days. Thus tolerance to the anti-seizure effects of NPY does not appe ar to develop rapidly. Tolerance being a problem with several current antie pileptic drugs, this further strengthens the concept of NPY receptors as a potential future antiepileptic target. (C) 2001 Elsevier Science Inc. All r ights reserved.