Effects of basic fibroblast growth factor on central nervous system functions

Basic fibroblast growth factor (bFGF), initially identified as mitogens wit h prominent angiogenic properties, is now recognized as multifunctional gro wth factors with notable actions on neuronal cells. bFGF promotes the survi val and neurite growth of brain neurons in vitro and in vivo, suggesting th at it functions as a neurotrophic factor. This effect of bFCF could be bene ficial for improving the survival of grafted neurons in transplantation. Fu rthermore, bFGF acutely modulates synaptic transmission in the hippocampus, suggesting that it has a role like a neurotransmitter ol neuromodulator. I n this article, we make a brief review of multiple biological activities of bFGF for brain neurons and discuss its potential usefulness for the treatm ent of neurodegenerative disorders including Alzheimer's disease and Parkin son's disease. (C) 2001 Academic Press.