Pentavalent rhenium-188 dimercaptosuccinic acid: a new kit formulation andits initial evaluation in mice

Authors
Pirmettis, I Limouris, GS Bouziotis, P Papadopoulos, M Knapp, FF Chiotellis, E
Citation
I. Pirmettis et al., Pentavalent rhenium-188 dimercaptosuccinic acid: a new kit formulation andits initial evaluation in mice, RADIOCH ACT, 89(2), 2001, pp. 115-118
Citations number
16
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
RADIOCHIMICA ACTA
ISSN journal
00338230 → ACNP
Volume
89
Issue
2
Year of publication
2001
Pages
115 - 118
Database
ISI
SICI code
0033-8230(2001)89:2<115:PRDAAN>2.0.ZU;2-0
Abstract
Pentavalent rhenium-188 dimercaptosuccinic acid [Re-188(V)DMSA] is a beta - emitting radiopharmaceutical that has been proposed for the treatment of pa inful bone metastases, medullary thyroid carcinoma and other soft tissue tu mours. In this study the development of a kit formulation for convenient, r outine preparation of Re-188(V)DMSA is presented. The kit contains all the ingredients in a single vial and its reconstitution with Re-188 perrhenate, up to 4 mt, produces Re-188(V)DMSA in high radiochemical purity, suitable for clinical application. Re-188(V)DMSA prepared by this kit method was eva luated in mice and resulted in a biodistribution pattern similar to that of Tc-99m(V)DMSA.