Prevalence of factor V Leiden and activated protein C resistance in central retinal vein occlusion

Purpose: Factor V Leiden is a common inherited mutation that is a significa nt risk factor for deep vein thrombosis, it results in resistance to activa ted protein C (APC). The association between factor V Leiden and central re tinal vein occlusion (CRVO) remains controversial. This study was designed to determine the prevalence of APC resistance and the factor V Leiden mutat ion in patients with CRVO in a controlled study. Methods: The study was designed as a case control study conducted in a tert iary care retina practice. The prevalence of APC resistance and factor V Le iden was determined by genetic testing of blood samples obtained from patie nts with CRVO and clinic control patients. Results: Factor V Leiden was identified in 2.3% of patients with CRVO and 3 .5% of clinic control patients. There was no significant association betwee n the presence of factor V Leiden and CRVO (odds ratio, 1.13; 95% confidenc e interval, 0.65-1.98; P = 0.66). Conclusion: Factor V Leiden does not appear to be associated with CRVO, Rou tine screening of patients with CRVO does not appear to be warranted.