Repetitive mucosal trauma promotes colon cancer in experimental rat model

Objective: to investigate the effect of repetitive mucosal trauma, anastomo sis and intestinal content on experimental colonic carcinogenesis as there is the possibility than non- specific colon lesions can promote cancer. Material and method: we performed to sixty female Sprague-Dawley rats a 4 c m colon loop defunctionalization with double colostomy (traumatic site). In testinal continuity was restored with an end-to-end cole-colic silk anastom osis. The surviving 47 rats were divided in 3 groups: Group A: 27 rats trea ted with I)MH. Group B: 10 rats treated with EDTA and Group C: Control of 1 0 rats. Animals were sacrificed 31-32 weeks after surgery for macro and mic ropathological studies. Results: in group A appeared 60 tumours: 44 in the functional colon, 20 of them in the anastomotic site; 8 in the non traumatised defunctionalized seg ment and 18 in the traumatised segment (p< 0.05). Conclusions: a) continuous microtraumas on colonic mucosa in rats are cance r promotional factors: b) silk suture in anastomosis promotes cancer.