Sex differences in the absence of massa intermedia in patients with schizophrenia versus healthy controls

Objective. To evaluate sexual dimorphism and incidence of absent massa inte rmedia (MI), a midline thalamic structure, in patients with schizophrenia a nd healthy controls. Methods. Thin slice magnetic resonance images of the brain were obtained. T he presence of MI was determined by viewing sagittal, coronal, and axial pl anes. Results. In healthy controls, females had a significantly lower incidence o f absent MI (13.56%) compared with males (32.08%). In patients with schizop hrenia, there was a sex by diagnosis interaction. Female patients had signi ficantly higher incidence of absent MI (32.76%) compared with their healthy controls (13.56%), whereas the male patients showed no difference in incid ence of absent MI compared with their controls. Conclusions. The MI, a sexually dimorphic midline structure, is more common ly absent in female patients with schizophrenia. These results support the growing literature reporting structural aberration of the thalamus, as well as other midline structures in the brains of patients with schizophrenia. (C) 2001 Elsevier Science B.V. All rights reserved.