Lipid distribution and transport across cellular membranes

In eukaryotic cells, the membranes of different intracellular organelles ha ve differ ent lipid composition, and various biomembranes show an asymmetri c distribution of lipid types across the membrane bilayer Membrane lipid or ganization reflects a dynamic equilibrium of lipids moving across the bilay er in both directions. In this review, we summarize data supporting the rol e of specific membrane proteins in catalyzing transbilayer lipid movement, thereby controlling and regulating the distribution of lipids over the leaf lets of biomembranes.