Photolabile group for 5 '-OH protection of nucleosides: synthesis and photodeprotection rate

Authors
Berroy, P Viriot, ML Carre, MC
Citation
P. Berroy et al., Photolabile group for 5 '-OH protection of nucleosides: synthesis and photodeprotection rate, SENS ACTU-B, 74(1-3), 2001, pp. 186-189
Citations number
9
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences","Instrumentation & Measurement
Journal title
SENSORS AND ACTUATORS B-CHEMICAL
ISSN journal
09254005 → ACNP
Volume
74
Issue
1-3
Year of publication
2001
Pages
186 - 189
Database
ISI
SICI code
0925-4005(20010415)74:1-3<186:PGF5'P>2.0.ZU;2-W
Abstract
In this paper, we described the properties of a new photolabile group, 2-(3 ,4-methylenedioxy-6-nitrophenyl)propoxycarbonayl MNPPOC. In spite of modera te yields of synthesis, photolytic properties could be analyzed for 5 ' -OH protected T and dA(iBU). The half-lives (t(1/2)) 11 and 12 s were found, r espectively with a good recovery of the corresponding deprotected deoxynucl eoside (95-99%). The photolysis rate of this new photolabile group was five -fold faster than the MeNPOC one. (C) 2001 Elsevier Science B.V. All rights reserved.