SYNTHESIS AND HEMOCOMPATIBILITIES OF NEW SEGMENTED POLYURETHANES AND POLY(URETHANE UREA)S WITH POLY(BUTADIENE) AND PHOSPHATIDYLCHOLINE ANALOGS IN THE MAIN CHAINS AND LONG-CHAIN ALKYL-GROUPS IN THE SIDE-CHAINS

Three new phospholipid diols, [2-(2-hydroxyethyldimethylammonio)ethyl] diethylene octadecylamine diphosphate (BDODP), 2-(2-hydroxyethyldimeth ylammonio)ethyl]-diethylene hexadecylamine diphosphate (BDHDP), and [2 -(2-hydroxyethyldimethylammonio)ethyl]diethylene dodecylamine diphosph ate (BDDDP), together with 1,4-butanediol (BD) or ethylenediamine (ED) as chain extender were further incorporated into the prepolymer of po ly(butadiene) glycol (PBD) and 4,4'-methylenediphenyl diisocyanate (MD I). The bulk and surface characteristics of the resulting phospholipid segmented polyurethanes (SPUs) and segmented poly(urethane urea)s (SP UUs) were investigated by infrared (IR), gel permeation chromatography (GPC), attenuated total reflectance Fourier transform infrared spectr oscopy (ATR-FTIR), electron spectroscopy for chemical analysis (ESCA), and contact angle measurements. The mechanical properties were invest igated by dynamic viscoelasticity. The hemocompatibilities of the new polymers were evaluated by platelet-rich plasma (PRP) contact studies and viewed by scanning electron microscopy (SEM) using medical BioSpan as a reference. It was found that the new polymers possessed relative ly hydrophobic surfaces revealed by contact angle measurements. Moreov er, the new materials have good surfaces in terms of platelet adhesion and that the morphology of adhered platelets undergoes a relatively l ow degree of variation.