Design, modeling and synthesis of functionalized paromamine analogs

Authors
Hanessian, S Tremblay, M Kornienko, A Moitessier, N
Citation
S. Hanessian et al., Design, modeling and synthesis of functionalized paromamine analogs, TETRAHEDRON, 57(16), 2001, pp. 3255-3265
Citations number
45
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
16
Year of publication
2001
Pages
3255 - 3265
Database
ISI
SICI code
0040-4020(20010416)57:16<3255:DMASOF>2.0.ZU;2-O
Abstract
Based on the published NMR structure of the antibiotic paromomycin complexe d with the A-site of Escherichia coli 16S ribosomal RNA, a set of C-5 funct ionalized analogs of paromamine was designed and synthesized, incorporating cyclic and acyclic appendages and terminating with one or more ammonium gr oups. (C) 2001 Elsevier Science Ltd. Ah rights reserved.