A new versatile methodology for the synthesis of 4-halogenated-6-diethylcarbamoylpyridine-2-carboxylic acids

Authors
Chauvin, AS Tripier, R Bunzli, JCG
Citation
As. Chauvin et al., A new versatile methodology for the synthesis of 4-halogenated-6-diethylcarbamoylpyridine-2-carboxylic acids, TETRAHEDR L, 42(17), 2001, pp. 3089-3091
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
17
Year of publication
2001
Pages
3089 - 3091
Database
ISI
SICI code
0040-4039(20010423)42:17<3089:ANVMFT>2.0.ZU;2-F
Abstract
Convenient syntheses of dipicolinic or chelidamic acid derivatives includin g 4-X-6-diethylcarbamoyl-pyridine-2-carboxylic acid (X = H, Cl, Br) and 4-c hloro-6-(3-oxo-3-phenylpropionyl)pyridine-2-carboxylic acid methyl ester ar e described. These compounds are important synthons for the synthesis of no n-symmetric tridentate aromatic chelating agents as well as for the design of ditopic ligands targeted for the elaboration of functional dimetallic he licates. (C) 2001 Elsevier Science Ltd. All rights reserved.