Synthesis of chiral non-racemic azetidines by lipase-catalysed acetylations and their transformation into amino alcohols: precursors of chiral catalysts

Azetidinic mono-acetate 7, diol 6b and di-acetate 10a were prepared with hi gh e.e. using PPL-catalysed acetylations. The absolute configurations of al l new enantioenriched compounds were assigned by chemical correlation with known compounds. Mono-acetate 7 was then transformed into 30, an amino alco hol of noteworthy potential interest since it represents an interesting pre cursor for chiral catalysts, such as 32. (C) 2001 Elsevier Science Ltd. All rights reserved.