A novel and effective chiral phosphoramide catalyst for the borane-mediated asymmetric reduction of prochiral alpha-halo ketones

Authors
Basavaiah, D Reddy, GJ Chandrashekar, V
Citation
D. Basavaiah et al., A novel and effective chiral phosphoramide catalyst for the borane-mediated asymmetric reduction of prochiral alpha-halo ketones, TETRAHEDR-A, 12(4), 2001, pp. 685-689
Citations number
20
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
4
Year of publication
2001
Pages
685 - 689
Database
ISI
SICI code
0957-4166(20010319)12:4<685:ANAECP>2.0.ZU;2-4
Abstract
The novel chiral phosphoramide, 1,4-bis[(5S)-1,3-diaza-2-phospha-2-oxo-3-ph enylbicyclo(3.3.0)octan-2-yl]piperazine, was synthesised and successfully e mployed as a catalyst in the borane-mediated asymmetric reductions of proch iral cc-halo ketones, providing the corresponding a-halo alcohols in 90-95% enantiomeric purities. (C) 2001 Elsevier Science Ltd. All rights reserved.