Stereocontrolled chemoenzymatic synthesis of 2,3-disubstituted piperidines

Authors
Monterde, MI Brieva, R Gotor, V
Citation
Mi. Monterde et al., Stereocontrolled chemoenzymatic synthesis of 2,3-disubstituted piperidines, TETRAHEDR-A, 12(3), 2001, pp. 525-528
Citations number
12
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
3
Year of publication
2001
Pages
525 - 528
Database
ISI
SICI code
0957-4166(20010305)12:3<525:SCSO2P>2.0.ZU;2-E
Abstract
(R,R)-2,3-Disubstituted piperidines were readily synthesized starting from (R)-(+)- 5-bromo-2-hydroxypentanenitrile (R)-2. An enantioselective (R)-oxy nitrilase-catalyzed transcyanation was used to prepare the starting cyanohy drin (R)-2. (C) 2001 Elsevier Science Ltd. All rights reserved.