T. Mahmood et al., CLOZAPINE IN THE MANAGEMENT OF BIPOLAR AND SCHIZOAFFECTIVE MANIC EPISODES RESISTANT TO STANDARD TREATMENT, Australian and New Zealand Journal of Psychiatry, 31(3), 1997, pp. 424-426
Objective: To test the efficacy of clozapine in treatment-resistant ma
nic episodes. Clinical picture: Three cases, two with bipolar disorder
(manic) and one of schizoaffective disorder (manic), were treated wit
h clozapine. Treatment: Clozapine was used after the failure of standa
rd antipsychotics and mood stabilisers. Outcome: All three cases were
successfully treated. Conclusion: A controlled trial of clozapine in t
reatment-resistant bipolar and schizoaffective manic episodes is indic
ated.