The first total syntheses of a variety of useful bioactive compounds ha ve
been accomplished by practically useful strategies. In addition, practicall
y useful intermediates have been developed, analogues of natural products h
ave been prepared, their structure-activity relationships studied, and the
large-scale preparations of medically useful compounds established. The tar
get molecules are antibiotics, antifungals, antitumor antibiotics, compound
s related to beta -lactam antibiotics, enzyme inhibitors, central nervous s
ystem-affecting products, non-steroidal progesterone receptor ligands, muss
el-attachment inhibitors, and so on.