The effect of local application of mitomycin-C on the development of capsule around silicone implants in the breast: An experimental study in mice

Citation
J. Frangou et M. Kanellaki, The effect of local application of mitomycin-C on the development of capsule around silicone implants in the breast: An experimental study in mice, AES PLAS SU, 25(2), 2001, pp. 118-128
Citations number
63
Categorie Soggetti
Surgery
Journal title
AESTHETIC PLASTIC SURGERY
ISSN journal
0364216X → ACNP
Volume
25
Issue
2
Year of publication
2001
Pages
118 - 128
Database
ISI
SICI code
0364-216X(200103/04)25:2<118:TEOLAO>2.0.ZU;2-G
Abstract
In this experimental study on mice we try to prove that capsule formation a round breast implants is considerably diminished after topical application of Mitomycin-C (MMC). MMC solution is applied under the breast tissue or pe ctoralis major muscle, in the pocket of the silicone implant and just befor e placing it. This is a morphological study of the connective tissue formed around the implant, under light and electron microscope. Our results sugge st that it is worthwhile working on a clinical study trying to prevent the most common complication of breast implants, contracture of a capsule.