Synthesis of some new spiropyrazoloheterocyclic derivatives

3-Methylpyrazolin-5-ones (1a,b) reacted with cycloalkanones (2a-d) in the p resence of fused sodium acetate gave the corresponding 3-methyl-4-cycloalky lidene-pyrazolin-5-ones (3a-h). Reaction of compounds 3a-h with hydrazine h ydrate, phenyl hydrazine, hydroxylamine hydrochloride, urea and thiourea af forded the corresponding spiropyrazolopyrazoles (4a-p), spiropyrazoloisoxaz oles (5a-h) and spiropyrazolopyrimidinones and spiropyrazolothiopyrimidinon es (6a-p) repectively. All the synthesized spiropyrazoloheterocyclic deriva tives were identified by conventional methods (IR,H-1 NMR) and elemental an alyses.