Change in tissue kallikrein level in nasal wash after the administration of oxatomide in patients with nasal allergy

Authors
Nishiyama, K Yao, K Iguci, Y Yamamoto, K Suzuki, T Sato, K Okamoto, M Majima, M
Citation
K. Nishiyama et al., Change in tissue kallikrein level in nasal wash after the administration of oxatomide in patients with nasal allergy, AM J RHINOL, 15(2), 2001, pp. 105-108
Citations number
19
Categorie Soggetti
Otolaryngology
Journal title
AMERICAN JOURNAL OF RHINOLOGY
ISSN journal
10506586 → ACNP
Volume
15
Issue
2
Year of publication
2001
Pages
105 - 108
Database
ISI
SICI code
1050-6586(200103/04)15:2<105:CITKLI>2.0.ZU;2-V
Abstract
The tissue kallikrein level in the nasal wash was measured before and after 4-week administration of oxatomide (30 mg per day) in 9 patients with pere nnial allergy. It was found that tissue kallikrein level in the nasal wash obtained following provocation tests significantly decreased from 6.05 +/- 4.43 (10(-10) mol/hour/L) to 1.84 +/- 0.93 (10(-10) mol/hour/L) after the a dministration of oxatomide. Improvement in subjective symptoms was also obs erved in all patients after the administration. These results would indicat e that kinin in the system is actively involved in the pathogenesis of nasa l allergy.