Serotype 19F multiresistant pneumococcal clone harboring two erythromycin resistance determinants [erm(B) and mef(A)] in South Africa

Authors
McGee, L Klugman, KP Wasas, A Capper, T Brink, A
Citation
L. Mcgee et al., Serotype 19F multiresistant pneumococcal clone harboring two erythromycin resistance determinants [erm(B) and mef(A)] in South Africa, ANTIM AG CH, 45(5), 2001, pp. 1595-1598
Citations number
24
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
5
Year of publication
2001
Pages
1595 - 1598
Database
ISI
SICI code
0066-4804(200105)45:5<1595:S1MPCH>2.0.ZU;2-I
Abstract
One hundred eighteen erythromycin-resistant Streptococcus pneumoniae (ERSP) strains (MICs of greater than or equal to0.5 mug/ml) from five laboratorie s serving the private sector in South Africa were analyzed for the genes en coding resistance to macrolides. Sixty-seven ERSP strains (56.8%) contained the erm(B) gene, and 15 isolates (12.7%) contained the mef(A) gene, Thirty -six isolates (30.5%) harbored both the erm(B) and mef(A) genes and were hi ghly resistant to erythromycin and clindamycin. DNA fingerprinting by BOX-P CR and pulsed-field gel electrophoresis identified 83% of these strains as belonging to a single multiresistant serotype 19F clone.