Prevention and treatment of lethal murine endotoxemia by the novel immunomodulatory agent MFP-14

Authors
Nicoletti, F Di Marco, R Sacerdote, P Meroni, P Mangano, K Edwards, C Bartorelli, A Bendtzen, K Panerai, A
Citation
F. Nicoletti et al., Prevention and treatment of lethal murine endotoxemia by the novel immunomodulatory agent MFP-14, ANTIM AG CH, 45(5), 2001, pp. 1591-1594
Citations number
26
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
5
Year of publication
2001
Pages
1591 - 1594
Database
ISI
SICI code
0066-4804(200105)45:5<1591:PATOLM>2.0.ZU;2-7
Abstract
Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits t he production of tumor necrosis factor alpha (TNF-alpha) and gamma interfer on (IFN-gamma), which are involved in the pathogenesis of sepsis. Here, lip opolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP -14. The treatment also lowered LPS-induced levels of TNF-alpha and IFN-gam ma in the blood.