Tolerance and pharmacokinetic interactions of rifabutin and azithromycin

Authors
Hafner, R Bethel, J Standiford, HC Follansbee, S Cohn, DL Polk, RE Mole, L Raasch, R Kumar, P Mushatt, D Drusano, G
Citation
R. Hafner et al., Tolerance and pharmacokinetic interactions of rifabutin and azithromycin, ANTIM AG CH, 45(5), 2001, pp. 1572-1577
Citations number
18
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
5
Year of publication
2001
Pages
1572 - 1577
Database
ISI
SICI code
0066-4804(200105)45:5<1572:TAPIOR>2.0.ZU;2-C
Abstract
This multicenter study evaluated the tolerance and potential pharmacokineti c interactions between azithromycin and rifabutin in volunteers with or wit hout human immunodeficiency virus infection. Daily dosing with the combinat ion of azithromycin and rifabutin was poorly tolerated, primarily because o f gastrointestinal symptoms and neutropenia. No significant pharmacokinetic interactions were found between these drugs.