2ND-ORDER KINETICS IN THE LIQUID-CHROMATOGRAPHIC REACTOR

Equations for the determination of second order rate constants with th e pulse overlay method, based on the application of empirical peak sha pe equations are derived. This approach was then applied in an experim ental study of the rection of pyridine with tetrachloroterephthaloyl c hloride in a reversed-phase HPLC system. Rate constants evaluated from reaction chromatograms were found to be in good agreement with those obtained earlier for this reaction by Chu and Langer in chromatographi c reactor experiments under pseudo-first order conditions.