Porous hydroxyapatite HA bodies were prepared with an aim to simulate bone
tissue morphology. By varying the characteristics of starting L-IA powders
and the impregnation strategy of cellulosic sponges with theologically opti
mized slurries, a wide range of physico-chemical and mechanical properties
of the porous ceramics can be obtained. The samples were characterized micr
ostructurally, by density and porosimetry and by mechanical strength. Cylin
drical specimens exhibiting a porosity gradient showed a promising behaviou
r after implantation in rabbits' femur: newly formed bone grew in tight con
tact with the ceramic in a very short time, no modified cells are induced a
nd bone tissue fills even the inner pores. (C) 2001 Elsevier Science Ltd. A
ll rights reserved.