A. Herizi et al., CARDIOPROTECTIVE EFFECT OF ENALAPRIL IN RENOVASCULAR AND ANGIOTENSIN-II HYPERTENSION, Clinical and experimental hypertension, 19(5-6), 1997, pp. 953-964
The influence of chronic treatment with enalapril or losartan (10 or 3
0mg/kg/24h, respectively) on cardiac mass was evaluated in one-kidney,
one clip (1K-1C) hypertensive rats submitted to sodium restriction 3
weeks after clipping and in rats infused for 10 days with angiotensin
II (ANGII: 200ng/kg/min). In 1K-1C hypertension, cardiac mass and arte
rial pressure were reduced to a similar extent by enalapril and losart
an. In ANGII hypertension, enalapril and losartan blunted the increase
in cardiac mass whereas losartan but not enalapril prevented the deve
lopment of hypertension. The cardioprotective effect of enalapril was
attenuated by concomitant blockade of bradykinin receptors (Hoe140: 30
0 mu/kg/24h) in both models. The beneficial influence of enalapril on
cardiac mass appears to be independent of its effect on blood pressure
and ANGII generation and seems partly mediated by endogenous bradykin
in in these high ANGII models of hypertension.