Antibody catalyzed modification of amino acids. Efficient hydrolysis of tyrosine benzoate

Authors
Benedetti, F Berti, F Colombatti, A Flego, M Gardossi, L Linda, P Peressini, S
Citation
F. Benedetti et al., Antibody catalyzed modification of amino acids. Efficient hydrolysis of tyrosine benzoate, CHEM COMMUN, (8), 2001, pp. 715-716
Citations number
21
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
8
Year of publication
2001
Pages
715 - 716
Database
ISI
SICI code
1359-7345(2001):8<715:ACMOAA>2.0.ZU;2-X
Abstract
Esterase antibody 522c2, the first example of a catalytic antibody specific ally programmed to control the reactivity of functional groups on the side chain of tyrosine, accelerates the hydrolysis of benzoate esters of l-tyros ine and tyrosine-containing dipeptides by a factor of 10(4) and is moderate ly active against other benzoate esters.