Glutathione S-transferase GSTT2 polymorphism and outcome in patients with colorectal cancer

We have developed polymerase chain reaction (PCR) based assays to examine 3 polymorphisms in GSTT2 in patients with colorectal cancer. Our results sug gest that two of the sites are in linkage disequilibrium with each other an d with GSTT1 genotype. Clinical parameters such as Duke's stage, differenti ation, tumour location, survival, family history and presence of nodes were also investigated. We identified significant associations between GSTT2 po lymorphisms and Dukeis stage. This preliminary data suggests that polymorph ism at GSTT2 may be significant in determining outcome in colorectal cancer . (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.