Lj. Zaharova et al., Activity of glutathione S-transferase in mice differing in susceptibility to o-aminoazotoluene-induced hepatocarcinogenesis, CHEM-BIO IN, 133(1-3), 2001, pp. 98-99
The potent hepatocarcinogen o-aminoazotoluene (OAT) induced predominantly c
ytochrome P-450 1A (CYP1A) enzymes which are responsible for its activation
. One of the detoxification routes include glutathione conjugate formation.
A comparative study on hepatic cytosol glutathione S-transferase (GST) act
ivity in mice differing in susceptibility to OAT-induced hepatocarcinogenes
is was conducted. We have estimated variation of the GST-activity after OAT
-induction. From the obtained results, one can conclude that the GST is not
the main determinant of the susceptibility to OAT-cancer. (C) 2001 Elsevie
r Science Ireland Ltd. All rights reserved.