Activity of glutathione S-transferase in mice differing in susceptibility to o-aminoazotoluene-induced hepatocarcinogenesis

The potent hepatocarcinogen o-aminoazotoluene (OAT) induced predominantly c ytochrome P-450 1A (CYP1A) enzymes which are responsible for its activation . One of the detoxification routes include glutathione conjugate formation. A comparative study on hepatic cytosol glutathione S-transferase (GST) act ivity in mice differing in susceptibility to OAT-induced hepatocarcinogenes is was conducted. We have estimated variation of the GST-activity after OAT -induction. From the obtained results, one can conclude that the GST is not the main determinant of the susceptibility to OAT-cancer. (C) 2001 Elsevie r Science Ireland Ltd. All rights reserved.