Glutathione S-transferase M1, M3, P1 and T1 in susceptibility to and outcome in patients with colorectal adenocarcinoma

We have investigated the role of GSTM1, M3, P1 and T1 in susceptibility to and outcome in patients with colorectal adenocarcinoma. We found that GSTM1 B and GSTT1 null were significantly associated with risk of developing thi s common cancer. GSTM1 B was significantly associated with improved surviva l in patients under 70 years at diagnosis, whilst GSTM3 BE was significantl y associated with reduced survival in those above this age. In addition, GS TT1 null was significantly associated with an earlier presentation, improve d survival in patients under 70 years at diagnosis and paradoxically reduce d survival in those above this age. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.