Evolution of the mammalian class-mu glutathione transferase gene cluster

Citation
Mq. Huang et al., Evolution of the mammalian class-mu glutathione transferase gene cluster, CHEM-BIO IN, 133(1-3), 2001, pp. 133-136
Citations number
3
Categorie Soggetti
Pharmacology & Toxicology
Journal title
CHEMICO-BIOLOGICAL INTERACTIONS
ISSN journal
00092797 → ACNP
Volume
133
Issue
1-3
Year of publication
2001
Pages
133 - 136
Database
ISI
SICI code
0009-2797(20010228)133:1-3<133:EOTMCG>2.0.ZU;2-A
Abstract
In humans, five class-mu glutathione transferase genes, GSTM1-5, are found clustered at chromosome 1p13.3. We have characterized the GSTM cluster in m acaques and partially characterized the cluster in mice. In macaques, the f ive GST Mu genes are closely related to their human orthologs but differ in the regions flanking the M1 deletion. Gene conversion of the intergenic re gions appears to have occurred after hominoids and old-world monkeys diverg ed 25 million years ago. Mice also have a similar tail-to-tail organization of in the mu-cluster, but the genes flanking the human GSTM3 (mouse mGSTM5 ) encode a novel cDNA, mGSTM7, and a possible pseudogene. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.