Sigma-class glutathione transferase from skin secretion of Xenopus laevis

Authors
Pennelli, A Ortolano, S Simmaco, M Miele, R Sacchetta, P Di Ilio, C
Citation
A. Pennelli et al., Sigma-class glutathione transferase from skin secretion of Xenopus laevis, CHEM-BIO IN, 133(1-3), 2001, pp. 234-236
Citations number
9
Categorie Soggetti
Pharmacology & Toxicology
Journal title
CHEMICO-BIOLOGICAL INTERACTIONS
ISSN journal
00092797 → ACNP
Volume
133
Issue
1-3
Year of publication
2001
Pages
234 - 236
Database
ISI
SICI code
0009-2797(20010228)133:1-3<234:SGTFSS>2.0.ZU;2-O
Abstract
Using GSH affinity chromatography followed by isoelectric focusing a GST is oform having an apparent molecular mass of 22.5 kDa and an isoelectric poin t at pH 5.1 was purified from the skin secretion of Xenopus laevis. Its N-t erminal amino acid sequence showed a highest similarity with the sigma GST class having the GSH dependent prostaglandin D2 synthase activity and found in the chicken (76% identity) and rat (66% identity) spleen cells. (C) 200 1 Elsevier Science Ireland Ltd. All rights reserved.