Prospective evaluation of the impact of amoxicillin, clarithromycin and their combination on human gastrointestinal colonization by Candida species

Citation
S. Maraki et al., Prospective evaluation of the impact of amoxicillin, clarithromycin and their combination on human gastrointestinal colonization by Candida species, CHEMOTHERA, 47(3), 2001, pp. 215-218
Citations number
12
Categorie Soggetti
Pharmacology,"Pharmacology & Toxicology
Journal title
CHEMOTHERAPY
ISSN journal
00093157 → ACNP
Volume
47
Issue
3
Year of publication
2001
Pages
215 - 218
Database
ISI
SICI code
0009-3157(200105/06)47:3<215:PEOTIO>2.0.ZU;2-U
Abstract
Amoxicillin and clarithromycin have been used extensively for the eradicati on of Helicobacter pylori, However, no study has examined the impact of the ir combination on the Candida albicans concentration of the gastrointestina l (GI) tract. This is the first study examining and comparing directly the effect of amoxicillin, clarithromycin and their combination on the C. albic ans concentration of the human GI tract. Methods: Thirty-three adult patien ts (11 in each antibiotic group) were studied prospectively. Quantitative s tool cultures for Candida were conducted at the beginning, the end and 1 we ek after the discontinuation of antibiotic treatment. Results: All three re gimens increased the GI colonization in patients by Candida. The combinatio n of amoxicillin with clarithromycin caused the highest increase; however, this was not statistically significant. Conclusion: Amoxicillin and clarith romycin used either alone or in combination cause a small to moderate incre ase in GI colonization by Candida. Hence, these drugs could be safely used in patients at risk for candidiasis originating from the GI tract. Copyrigh t (C) 2001 S. Karger AG, Basel.