Detection of cranial metastases by F-18FDG positron emission tomography

Fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) sca nning has been useful in the management of various cancers. The normal gluc ose use of gray matter often limits the detection of metastatic lesions to the brain and skull with FDG PET. The authors report two cases of calvarial metastases: one with pheochromocytoma and the other with non-small-cell lu ng carcinoma, These cases illustrate the crucial role that FDG PET can play when patients are examined for metastases, The important concept of contra st resolution that is achieved with PET imaging is discussed as an advantag e that significantly overcomes its limited spatial resolution in detecting small lesions that may not be detected by anatomic imaging techniques with high spatial resolution.