Potential uses of computed tomography-SPECT and computed tomography-coincidence fusion images of the chest

The ability to fuse (or merge) data sets from SPECT and coincidence nuclear medicine scans with computed tomographic images combines physiologic infor mation from the former method with the superior anatomic resolution of the latter technique. In many cases, this allows more definitive diagnosis than can be obtained by simple visual comparison of nuclear medicine images and conventional cross-sectional imaging. The technique may be used in the sta ging and follow-up of lung carcinoma, pulmonary carcinoid, and lymphoma. It may also aid in the interpretation of perfusion defects in Tc-99m MAA lung scanning, aid in the interpretation of ground-glass opacity in selected ca ses of chest high-resolution computed tomography, and aid in the diagnosis of some mediastinal masses (e.g,, intrathoracic goiters), In this nuclear m edicine atlas, the method used to create fusion images in the chest is desc ribed, and examples of fusion imaging with radiopharmaceuticals are given t hat may be of clinical use in chest disease.