17-BETA-ESTRADIOL PROTECTS AGAINST NMDA-INDUCED EXCITOTOXICITY BY DIRECT INHIBITION OF NMDA RECEPTORS

Authors
WEAVER CE PARKCHUNG M GIBBS TT FARB DH
Citation
Ce. Weaver et al., 17-BETA-ESTRADIOL PROTECTS AGAINST NMDA-INDUCED EXCITOTOXICITY BY DIRECT INHIBITION OF NMDA RECEPTORS, Brain research, 761(2), 1997, pp. 338-341
Citations number
30
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
761
Issue
2
Year of publication
1997
Pages
338 - 341
Database
ISI
SICI code
0006-8993(1997)761:2<338:1PANEB>2.0.ZU;2-8
Abstract
Several lines of evidence suggest that 17 beta-estradiol (beta E-2) ha s neuroprotective properties. The risk and severity of dementia are de creased in women who have received estrogen therapy, and beta E-2 prot ects neurons in vitro against death from a variety of stressors. Neuro protection by beta E-2 has been suggested to be due to free radical sc avenging. We demonstrate an additional neuroprotective mechanism where by beta E2 protects against NMDA-induced neuronal death by directly in hibiting the NMDA receptor. (C) 1997 Elsevier Science B.V.