COORDINATE REDUCTION IN CELL-PROLIFERATION AND CELL-DEATH IN MOUSE OLFACTORY EPITHELIUM FROM BIRTH TO MATURITY

We investigated cell proliferation and cell death in the olfactory epi thelium (OE) of mice from birth to maturity using bromodeoxyuridine an d terminal deoxynucleotidyl transferase nick end labeling. We show tha t cell death events and proliferative activity diminish concomitantly with age in the OE. Thus, the age-dependent and coordinate diminution in cell proliferative activity and cell death events may serve to main tain the thickness of the OE as mice mature and age. (C) 1997 Elsevier Science B.V.