Delta FosB: a molecular switch underlying long-term neural plasticity

Authors
Kelz, MB Nestler, EJ
Citation
Mb. Kelz et Ej. Nestler, Delta FosB: a molecular switch underlying long-term neural plasticity, CURR OP NEU, 13(6), 2000, pp. 715-720
Citations number
54
Categorie Soggetti
Neurology
Journal title
CURRENT OPINION IN NEUROLOGY
ISSN journal
13507540 → ACNP
Volume
13
Issue
6
Year of publication
2000
Pages
715 - 720
Database
ISI
SICI code
1350-7540(200012)13:6<715:DFAMSU>2.0.ZU;2-K
Abstract
Numerous chronic perturbations have been shown to induce highly stable isof orms of the transcription factor Delta FosB in the brain in a region-specif ic manner. This review examines the functional consequences of the inductio n of Delta FosB in particular neuronal populations as well as its possible role in behavioral abnormalities such as drug addiction and movement disord ers. Curr Opin Neurol 13:715-720. (C) 2000 Lippincott Williams & Wilkins.